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KMID : 0861020120270040081
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Korea Journal of Herbology
2012 Volume.27 No. 4 p.81 ~ p.88
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Effects of Banhahubak-tang Extract on Psychological Stress
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Lim Se-Hyun
Jeong Hyun-Yun
Won Ho-Young
Kim Hyung-Woo
Choi Chang-Won
Jeong Hyang-Sook
Kim Young-Kyun
Cho Su-In
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Abstract
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Objective: Banhahubak-tang is indicated for globus hystericus, marked by a subjective sensation as if something stuffed in the throat, chest distress, cough or vomiting, greasy whitish, taut and smooth pulse. In this study, the effects of Banhahubak-Tang extract (BHTe) were tested for anti-stress action.
Methods: BHTe was extracted by pure water using electronic extractor and then fed to ICR male mice (20±2g) orally with the dose of 100㎎/㎏/day for five days. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days.
Results: BHTe administered group showed a tendency of decreasing of serum corticosterone secretion when compared with control group, and BHTe administration also significantly up-regulated noradrenaline secretions in the dorsal cortex of brain. Lipid peroxidation of the brain tissues of mice were tested by measuring malondialdehyde, but BHTe showed no significant change. The elevated plus-maze test was designed to detect the effect of anxiolytic drugs, and BHTe administered group showed a significant increase of latency time.
Conclusions: These results suggest that BHTe can effectively rid the psychological stress and it’s related diseases.
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KEYWORD
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Banhahubak-tang extract, BHTe, psychological stress, corticosterone, noradrenaline, Lipid peroxidation, anti-anxiety effect
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